SS-31 / Elamipretide: A Peptide Targeting the Mitochondrial Membrane
Medically reviewed by: Op. Dr. Ferhat İlen, ENT – Head & Neck Surgeon · Last updated:
SS-31 is a tetrapeptide engineered to stabilize the mitochondrial electron transport chain by binding to cardiolipin on the inner membrane. It received accelerated approval for Barth syndrome, a rare genetic disorder.
Regulatory / evidence status: FDA accelerated approval (September 2025, Forzinity): Barth syndrome only. Not approved for aging or athletic performance.
In the Context of Longevity
Animal studies show favorable findings in age-related mitochondrial dysfunction; however, clinical evidence that it slows aging in healthy humans is lacking.
Frequently asked questions
Is SS-31 safe?
Injection site reactions were most commonly reported in clinical trials; long-term safety data remain limited.
References
This page is for information only and does not replace diagnosis, treatment advice or a prescription. Peptide and drug assessments are made only after a physician consultation. No results are guaranteed.
Ask your physician whether it is right for you