MOTS-c: exercise-mimetic mitochondrial peptide
Medically reviewed by: Op. Dr. Ferhat İlen, ENT – Head & Neck Surgeon · Last updated:
MOTS-c is a 16-amino-acid peptide encoded by mitochondrial DNA. Mouse studies have shown that it improves insulin sensitivity and physical capacity.
Regulatory / evidence status: Under investigational research; not an approved medication and banned by WADA.
Level of evidence
In humans, endogenous MOTS-c levels have been observed to increase with exercise; however, exogenous administration has not been shown to provide clinical benefit in humans.
Realistic alternative
Interventions supported by the strongest evidence for mitochondrial health remain structured endurance and resistance training, restorative sleep, and metabolic optimization.
Frequently asked questions
Does MOTS-c promote weight loss?
Anti-obesity effects have been observed in murine models; robust evidence in humans is lacking.
References
This page is for information only and does not replace diagnosis, treatment advice or a prescription. Peptide and drug assessments are made only after a physician consultation. No results are guaranteed.
Ask your physician whether it is right for you